[HTML][HTML] Kinetic competition between RNA Polymerase II and Sen1-dependent transcription termination
DZ Hazelbaker, S Marquardt, W Wlotzka, S Buratowski - Molecular cell, 2013 - Elsevier
The essential helicase-like protein Sen1 mediates termination of RNA Polymerase II (Pol II)
transcription at snoRNAs and other noncoding RNAs in yeast. A mutation in the Pol II
subunit Rpb1 that increases the elongation rate increases read-through transcription at
Sen1-mediated terminators. Termination and growth defects in sen1 mutant cells are
partially suppressed by a slowly transcribing Pol II mutant and are exacerbated by a faster-
transcribing Pol II mutant. Deletion of the nuclear exosome subunit Rrp6 allows visualization …
transcription at snoRNAs and other noncoding RNAs in yeast. A mutation in the Pol II
subunit Rpb1 that increases the elongation rate increases read-through transcription at
Sen1-mediated terminators. Termination and growth defects in sen1 mutant cells are
partially suppressed by a slowly transcribing Pol II mutant and are exacerbated by a faster-
transcribing Pol II mutant. Deletion of the nuclear exosome subunit Rrp6 allows visualization …
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